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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientific publication with restrictions compared to Guideline Study (limited documentation)

Data source

Reference
Reference Type:
publication
Title:
The inhalation toxicity of phenylglycidyl ether. I. 90-day inhalation study
Author:
James B. Terrill, Ki P. Lee
Year:
1977
Bibliographic source:
Toxicology and Applied Pharmacology, Volume 42, Issue 2, November 1977, Pages 263-269

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other:
Deviations:
yes
Remarks:
limited documentation
GLP compliance:
not specified
Test type:
other:

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
name: phenylglycidyl ether (PGE)
no further data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
weight at study initiation. 250 - 260 g (male), 180-200 g (female)

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
vapour generated from liquid heated to a polymer process temperature of 310°C
Duration of exposure:
6 h
Remarks on duration:
per day
Concentrations:
1, 5, and 12 ppm (v/v) of phenylglycidyl ether (PGE)
No. of animals per sex per dose:
6 per dose
Details on study design:
exposure for 6 hr/day, 5 days/week for 90 days (63 exposures) to atmospheres of 1, 5, and 12 ppm (v/v) of phenylglycidyl ether (PGE) vapors

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: approximale lethal dose
Effect level:
323 ppm
Based on:
other:
Mortality:
no
Clinical signs:
other: hair loss
Body weight:
decreaseed body weights in all dose groups
Other findings:
Microscopic comparison of 32 other major organs and tissues from test and control animals showed no compound-related effects. Likewise, no differences between test and control groups were seen relative to body weight, hematologic, urinanalytical, or biochemical indices. The hair loss was probably attributable to a mild focal skin irritation from PGE vapor and not to a systemic effect of inhaled PGE.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information