Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-557-2 | CAS number: 122-60-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1954-1956
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific publications and secondary literature with restrictions compared to Guideline Study (limited documentation)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The toxicology of glycidol and some glycidyl ethers
- Author:
- Anderson, H. H. Dunlap, M. K. Hine, C. H. Kodama, J. K. Wellington, J. S.
- Year:
- 1 956
- Bibliographic source:
- Anderson, H. H., M. K. Dunlap, et al. (1956). The toxicology of glycidol and some glycidyl ethers. Archives of industrial health 14(3): 250-264.
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List V
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC
- Year:
- 1 954
- Bibliographic source:
- Arch. Ind. Hyg. Occupational Med. 10, 61-68
- Reference Type:
- review article or handbook
- Title:
- PROCTOR AND HUGHES’ CHEMICAL HAZARDS of the WORKPLACE
- Author:
- Gloria J. Hathaway, Ph.D. Nick H. Proctor, Ph.D.
- Year:
- 2 004
- Bibliographic source:
- PHENYL GLYCIDYL ETHER in: PROCTOR AND HUGHES’ CHEMICAL HAZARDS of the WORKPLACE, pg 573
- Reference Type:
- secondary source
- Title:
- MAK Begrüngung - Phenylglycidyl ether
- Author:
- German MAK Kommission
- Year:
- 1 991
- Bibliographic source:
- MAK Begrüngung - Phenylglycidyl ether (1991)
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- PGE; Phenoxypropenoxide; 2,3-
- IUPAC Name:
- PGE; Phenoxypropenoxide; 2,3-
- Details on test material:
- Name: Phenylglycidyl ether
CAS: 122-60-1
Synonyms: PGE; Phenoxypropenoxide; 2,3-
epoxypropyl phenyl ether
Physical Form. Colorless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: internal breeding
- Weight at study initiation: from 90 to 120 g
- Fasting period before study: no
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: water, corn oil, or a 1 % solution of sodium 3,9-diethyl-6-tridecanol sulfate
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- 5
- Details on study design:
- no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 260 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 900 - 4 660
- Remarks on result:
- other: Smyth et. al
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 850 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 3 110 - 4 780
- Remarks on result:
- other: Anderson et. al
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
