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Toxicological information

Carcinogenicity

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Description of key information

Read-across from 2 year carcinogenicity studies in rats and mice  (monosodium salt and monosodium monohydrate salt of cyanuric acid were non-oncogenic by the oral route). Trisodium cyanurate is also considered non-oncogenic at the same conditions.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Dose descriptor:
NOAEL
176.5 mg/kg bw/day

Additional information

Read-across:

1. Based on the experimental results obtained with the analogue monosodium salt of cyanuric acid, monohydrate (NOAEL ca. 154 mg/kg bw/day, male and NOAEL ca. 266 mg/kg bw/day, female) and the molecular weights, the read-across approach is applied and the NOAEL for substance trisodium cyanurate is calculated to be 176.5 mg/kg bw/day

(male) and 304.9 mg/kg bw/day (female).

2. Based on the experimental results obtained with the analogue monosodium salt of cyanuric acid (NOAEL ca. 1520  mg/kg bw/day, male and NOAEL ca. 1580 mg/kg bw/day, female) and the molecular weights, the read-across approach is applied and the NOAEL for substance trisodium cyanurate are calculated to be ca. 1948.9 mg/kg bw/day, male and 2025.8 mg/kg bw/day, female.

Justification for classification or non-classification

In both studies, under the experimental conditions, there is no evidence of carcinogenic potential of the test material