Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EC B.14(Ames test)
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
β-methyl-3-(1-methylethyl)benzenepropanal
EC Number:
412-050-4
EC Name:
β-methyl-3-(1-methylethyl)benzenepropanal
Cas Number:
125109-85-5
Molecular formula:
C13H18O
IUPAC Name:
3-[3-(propan-2-yl)phenyl]butanal

Method

Species / strain
Species / strain / cell type:
other: S. typhimurium TA 98, TA 100, TA 1535, TA 1537 and TA 1538
Metabolic activation:
with
Metabolic activation system:
S9-Mix(rat liver cell fraction)
Vehicle / solvent:
Solvent: DMSO

Results and discussion

Test results
Species / strain:
other: S. typhimurium TA 98, TA 100, TA 1535, TA 1537 and TA 1538
Metabolic activation:
not specified
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not specified
Additional information on results:
Observations:
No genetic activity of the test material in any of the assays.
Remarks on result:
other: other: S9-Mix(rat liver cell fraction)
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation