Registration Dossier

Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EC B.14(Ames test)
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
β-methyl-3-(1-methylethyl)benzenepropanal
EC Number:
412-050-4
EC Name:
β-methyl-3-(1-methylethyl)benzenepropanal
Cas Number:
125109-85-5
Molecular formula:
C13H18O
IUPAC Name:
β-methyl-3-(1-methylethyl)benzenepropanal

Method

Species / strain
Species / strain / cell type:
other: S. typhimurium TA 98, TA 100, TA 1535, TA 1537 and TA 1538
Metabolic activation:
with
Metabolic activation system:
S9-Mix(rat liver cell fraction)
Vehicle / solvent:
Solvent: DMSO

Results and discussion

Test results
Species / strain:
other: S. typhimurium TA 98, TA 100, TA 1535, TA 1537 and TA 1538
Metabolic activation:
not specified
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not specified
Additional information on results:
Observations:
No genetic activity of the test material in any of the assays.
Remarks on result:
other: other: S9-Mix(rat liver cell fraction)
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation