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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.

Data source

Reference
Reference Type:
other: SNIF
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: ATC-Methode (Acute Toxic Class Methode) E.Schlede, U.Mischke R.Roll, D.Kayser: "A national validation study of the acute- toxic-class methode..." Arch. Toxicol. 66: 455-470 (1992)
Deviations:
not specified
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Body responsible for the test
IUPAC Name:
Body responsible for the test
Test material form:
not specified

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
olive oil
Doses:
Male: 2200 mg/kg bw
Female: 2200 mg/kg bw
No. of animals per sex per dose:
Male: number of animals 3
Female: number of animals 3
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 200 mg/kg bw
Based on:
not specified
Mortality:
Male: 2200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Gross pathology:
Effects on organs: Without findings

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: EU-GHS
Conclusions:
LD50 (male/female) > 2200 mg/kg bw