Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The sensitisation potential of D6N-acetate was assessed using a method based on the maximisation test described by Magnusson and Kligman (1970). The study involved the treatment of guinea pigs using two procedures: the potential induction of an immune response and a challenge by assessing the degree of erythema.

Following challenge of previously induced guinea pigs with a 92% or a 75% w/v preparation of the test substance in corn oil, no erthematous response was seen on any of the test or control animals. A positive control study using hexylcinnamaldehyde demonstrated the sensitivity of the test system.

D6N-acetate and D6N, by read across, are not skin sensitisers under the conditions of the test.

Migrated from Short description of key information:
Based on read-across from similar substance, D6N is not sensitising.

Justification for classification or non-classification

Based on read-across from similar substance, D6N is not sensitising.