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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: short report but sufficient information to be taken into account

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
Single oral application of 5 different doses of test substance in lutrol to 10 male Wistar rats/dose . Observation for clinical signs and mortal was done for: 14 days; calculation of LD50 was done according to Fink und Hund (1965): Arzneimittel Forschung 15, 624
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Naphthalene-1,5-diol
EC Number:
201-487-4
EC Name:
Naphthalene-1,5-diol
Cas Number:
83-56-7
Molecular formula:
C10H8O2
IUPAC Name:
naphthalene-1,5-diol
Test material form:
other: solid
Details on test material:
no details given

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
body weight at study start: 160 - 180 g
5 aninmals/cage
no further data given

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: lutrol
Details on oral exposure:
Single oral application of different doses in lutrol to 10 male rats/dose
Doses:
100, 500, 800, 1000, 1200 mg/kg bw
No. of animals per sex per dose:
10 males
Control animals:
no
Details on study design:
Single oral application of 5 different doses of test substance in lutrol to 10 male Wistar rats/dose .
Observation period for clinical signs and mortality: 14 days.
Calculation of LD50: according to Fink und Hund (1965): Arzneimittel Forschung 15, 624
Statistics:
Calculation of LD50 according to Fink und Hund (1965): Arzneimittel Forschung 15, 624

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
660 mg/kg bw
95% CL:
>= 480 - <= 790
Remarks on result:
other: tremor, cramps and prone position
Mortality:
100 mg animals survived
500 mg-group: 3/10 within 2-3 d after application
800 mg-group 5/10 within 2-3 days after application
1000 mg-group 9/10 within 2 days after application
1200 mg-group: 10/10 within 1 h after application
Clinical signs:
other: tremor, prone position, cramps, crying
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Executive summary:

Single oral application of up to 1200 mg/kg bw to 10 male Wistar rats per dose group and observation for 14 days. 100 mg/kg bw was tolerated without mortality or clinical signs. All other animals displayed tremor, cramps. prone position and cry before death occurred: 2 -3/10 at 500 mg/kg bw up to 10/10 at the highest test dose.. LD50 is 660 mg/kg bw