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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Available as short summary from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
The excretion and tissue distribution of [14C]-p-methylanisole in the rat after topical application. Report to RIFM.
Author:
D.R. Hawkins, B.C. Mayo, A.d. Pollard and W.W. Donschak
Year:
1993
Bibliographic source:
cited in the RIFM/FEMA database; Location 21041

Materials and methods

Principles of method if other than guideline:
Assessment of excretion and tissue distribution of radioactive p-methylanisole after topical application in the rat
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methylanisole
EC Number:
203-253-7
EC Name:
4-methylanisole
Cas Number:
104-93-8
Molecular formula:
C8H10O
IUPAC Name:
1-methoxy-4-methylbenzene
Details on test material:
- Name of test material (as cited in study report): (14)C-p-methylanisole
Radiolabelling:
yes
Remarks:
(14)C-p-methylanisole

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: diethyl phthalate
Duration of exposure:
6 hours
Doses:
- Nominal doses: 100, 320 & ca. 1000 mg/kg bw
No. of animals per group:
4
Details on study design:
REMOVAL OF TEST SUBSTANCE
Dressing & residual dose were removed using cotton wool swabs moistened with diethyl phthalate.

SAMPLE COLLECTION
Urine, faeces & expired air were collected for 72 hours after dose application. At this time, rats were killed & whole blood & tissues were taken for measurement of radioactivity.

Results and discussion

Signs and symptoms of toxicity:
not specified
Dermal irritation:
not specified
Total recovery:
Radioactivity recovered from each group of rats dosed accounted for means of about 94-97% of the (14)C-p-methylanisole administered.
Percutaneous absorptionopen allclose all
Dose:
100 mg/kg bw
Parameter:
percentage
Absorption:
ca. 23 %
Remarks on result:
other: 72 hours
Remarks:
No data available given for whole blood/tissues
Dose:
320 mg/kg bw
Parameter:
percentage
Absorption:
ca. 35 %
Remarks on result:
other: 72 hours
Remarks:
No data available given for whole blood/tissues
Dose:
1000 mg/kg bw
Parameter:
percentage
Absorption:
ca. 57 %
Remarks on result:
other: 72 hours
Remarks:
No data available given for whole blood/tissues

Any other information on results incl. tables

1000 mg/kg bw:  

Total excretion via urine: 20% of dose

Total excretion via feces: 0.05-0.17% of dose

Radioactivity in expired air: 37% of dose

Recovery from washings of treated skin after 6 hours: 36% of dose

320 mg/kg bw:  

Total excretion via urine: 12% of dose

Total excretion via feces: 0.05-0.17% of dose

Radioactivity in expired air: 23% of dose

Recovery from washings of treated skin after 6 hours: 59% of dose

100 mg/kg bw:  

Total excretion via urine: 12% of dose

Total excretion via feces: 0.05-0.17% of dose

Radioactivity in expired air: 11% of dose

Recovery from washings of treated skin after 6 hours: 74% of dose

At 72 hours after dosing 0.02-0.05% of the dose was in the treated skin taken from these rats after being killed.

Applicant's summary and conclusion