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EC number: 938-868-6 | CAS number: -
Table 1. Clinical signs.
Dose(mg/kg of body mass)
Day following administration
Number of live animals
* females from the initial experiment
BZ = without change
OK = clinical symptoms observed
P = died
Table 2. Body weights
mg/kg of body mass
Day of experiment
14 – 0
A study was conducted to test oral toxicity potential of Cu (II) IDHA in rats. Following the single administration of the analysed substance at dose level of 2000 mg/kg bw to a single female Wistar rat symptoms of toxicity were observed within the first hour of administration. The female died within the second hour of administration of the analysed material. Following the single administration of the analysed substance at dose level of 300 mg/kg bw to a single female, no symptoms of toxicity were observed during the 14-day period of observation. The female survived the 14-day period of observation. Based on this result, the test substance at the dose level of 300 mg/kg bw was administered to four successive females. No symptoms of toxicity were observed during the 14-day period of observation for three of the animals. In one animal, symptoms of toxicity were observed from the seventh day of observation. In all probability, these changes were not connected with the analysed material. The female died on the tenth day of observation. The remaining females survived the 14-day observation period.
The females that died (initial and main studies) and the remaining females that survived the 14-day period of observation underwent autopsies and macroscopic studies.
The macroscopic study of the female that died having received the dose of 2000 mg/kg bw disclosed hepatic hyperaemia, as well as pale and enlarged lungs. No changes were found during the macroscopic study in the female that died having received the dose of 300 mg/kg bw (the animal was devoured by the other animals present in the cage). Macroscopic studies did not find any pathological changes in the remaining animals.
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