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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not stated
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Non-GLP study with no information on methods to determine acceptability of study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Principles of method if other than guideline:
No information available.
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
(R)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
EC Number:
224-815-8
EC Name:
(R)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
Cas Number:
4501-58-0
Molecular formula:
C10H16O
IUPAC Name:
(R)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
Details on test material:
- Name of test material: Aldehyde Campholenique

Test animals

Species:
rabbit

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Doses:
5 g/kg
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
other: Prostration, yellow exudate at nose, ataxia, ptosis, respiratory distress, lethargy, diarrhea, abdomen bloated, emaciated, mucous in stool, alopecia
Other findings:
SKIN IRRITATION
Redness day 1 - none 3/10; severe 7/10
Oedema, moderate - 10/10

Any other information on results incl. tables

Table 1: Necropsy observations

 5.00 g/kg
 Exudate, nose/mouth, yellow  1
Anogenitial, areas yellow  4
 Intestines, bloated  4
 Lungs, areas dark  2
 Kidney, mottled  1
 Lungs, bright orange  3
 Skin, edema  6
 Skin, redness  6
 Skin hard/thick  2

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of the test, the acute dermal toxicity of the test substance was determined to be LD50 >5000 mg/kg.
Executive summary:

In a non-GLP acute dermal toxicity study, the acute dermal toxicity of the test substance was determined to be LD50 >5000 mg/kg.