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EC number: 219-145-8 | CAS number: 2372-82-9
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data estimated using MPBPWIN model of the EPI Suite v.3.12 QSAR software. The estimation error of this method increases as the vapor pressure decreases, especially when the vapor pressure decreases below 1x10-6 mm Hg (0.0001333 Pascals).
- Principles of method if other than guideline:
- Method: EPI Suite v3.12
- GLP compliance:
- no
- Type of method:
- other: calculation
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: estimated using modified grain method
- Conclusions:
- The vapour pressure of the substance was estimated to be 0.000199 Pa at 25°C.
- Executive summary:
A study was conducted to determine the vapour pressure of the test substance using the MPBPWIN model of the EPI Suite v.3.12 QSAR software. Under the study conditions, the vapour pressure of the substance was 0.000199 Pa at 25°C (EPI Suite v 3.12, 2006).
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 08, 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- Cited as Directive 92/69/EEC, A.4
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- Under the study conditions, the vapour pressure of the test substance was found to be 0.00014 Pa at 25°C
- Executive summary:
A study was conducted to determine the vapour pressure of the test substance using an effusion method according to the EU Method A.4, in compliance with GLP. The vapour pressure was determined using a vapour pressure balance with measurements being made at several temperatures and linear regression analysis was used to calculate the vapour pressure at 25°C. Under the study conditions, the vapour pressure of the test substance was found to be 0.00014 Pa at 25°C (Tremain, 2002).
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- Under the study conditions vapour pressure of the test substance was established to be 5.45E-05 Pa at 25.0°C.
- Executive summary:
A study was conducted to determine the vapour pressure according to EU Method A.4 (effusion method) using Knudsen cells method. Under the study conditions vapour pressure of the test substance was established to be 5.45E-05 Pa at 25.0°C (Flack, 1996).
Referenceopen allclose all
Henry´s Law Constant (calculated): result (25°C):
Vapour Pressure Estimations (25°C):
VP: 4.2E-007 mm Hg (= 0.000056 Pa), (Antoine Method)
VP: 1.49E-006 mm Hg (= 0.000199 Pa), (Modified Grain Method)
VP: 3.17E-006 mm Hg (= 0.00042 Pa), (Mackay Method)Selected VP value: 1.49E-006 mm Hg (Modified Grain Method) ( = 0.000199 Pa)
Run Log10 [VP(25 °C)
1 -3.568
2 -3.756
3 -3.921
4 -3.954
5 -4.186
6 -3.822
mean -3.868
VP: 1.4x10-4 Pa
The test substance did not change in appearance under the conditions used in the test.
Description of key information
Determination of the vapour pressure according to:
- EU Method A.4 (Tremain, 2002; Flack, 1996)
- QSAR (EPI Suite v 3.12, 2006)
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 25 °C
Additional information
- 0.00014 Pa at 25°C (Tremain, 2002)
- 5.45E-05 Pa at 25.0°C (Flack, 1996)
- 0.000199 Pa at 25°C (EPI Suite v 3.12, 2006)
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