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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Short summary of results; russian translation

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Astapova, S.A. et al.
Year:
1990
Bibliographic source:
Gigiena i sanitarija 55: 86

Materials and methods

Principles of method if other than guideline:
Mice are continuously exposed to vapours of the test substance for 24h/day over a period of 4 months.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl adipate
EC Number:
203-350-4
EC Name:
Dibutyl adipate
Cas Number:
105-99-7
Molecular formula:
C14H26O4
IUPAC Name:
1,6-dibutyl hexanedioate
Details on test material:
- Name of test material (as cited in study report): DBA
- Analytical purity: no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
yes
Details on analytical verification of doses or concentrations:
gas chromatography
Duration of treatment / exposure:
4 months
Frequency of treatment:
continuous treatment (24 h/day; 7 days/week)
Doses / concentrations
Remarks:
Doses / Concentrations:
5.0 ± 0.1, 0.45 ± 0.02 and 0.044 ± 0.003 mg/m³ air
Basis:
analytical conc.
No. of animals per sex per dose:
no data

Results and discussion

Results of examinations

Details on results:
The same LIMch (limit dose after chronic exposure) was derived for mice treated under the same conditions as the rats in this study.

Effect levels

Dose descriptor:
other: LIMch
Effect level:
0.45 mg/m³ air (analytical)
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: change in reflex activity; barriere change of neuromuscular stimulation: LIMac = 4.8 mg/m³

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion