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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range finding toxicity data: List IV
Author:
Smyth, H.F. Jr., et al.
Year:
1951
Bibliographic source:
Arch Ind Hyg Occup Med 4(2):119-22
Reference Type:
publication
Title:
The place of the range findings test in the industrial toxicology laboratory
Author:
Smyth, H.F. Jr. and Carpenter, C.P.
Year:
1944
Bibliographic source:
as cited in: Journal of industrial hygiene and toxicology 26 (8): 269-273
Reference Type:
secondary source
Title:
Diesters Category of the Aliphatic Esters Chemicals (Test Plan and Robust Summaries for Substances in the HPV Test Plan)
Author:
US-EPA (American Chemistry Council's Aliphatic Esters Panel)
Year:
2010
Bibliographic source:
High Production Volume (HPV) Chemical Challenge Program (201-16837A and 201-16837B)

Materials and methods

Principles of method if other than guideline:
Application of a single oral dose to rats.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl adipate
EC Number:
203-350-4
EC Name:
Dibutyl adipate
Cas Number:
105-99-7
Molecular formula:
C14H26O4
IUPAC Name:
1,6-dibutyl hexanedioate
Details on test material:
- Name of test material (as cited in study report): Dibutyl adipate
- Analytical purity: no data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Additional information on strain: albino Wistar strain rats (or if necessary rats of other strains, as previously reported by the authors (1944))
- Weight at study initiation: 90 - 120 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

6 male rats were given a single dose of the test substance. One week later six more animals were given some other dosage and this procedure was repeated until two dosages differing by a multiple of ten were found one of which kills some or all animals and the other of which kills some or no animals within 14 days. An LD50 was then estimated on the assumption that the slope of a probit mortality vs. log dosage curve is the same as that of some structurally similar material which has been studied in more detail previously.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
12 900 mg/kg bw
Based on:
test mat.
95% CL:
> 6.6 - < 17

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
CLP: not classified
DSD: not classified