Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short summary available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
A plaster which was soaked with test substance was put on the forearm of 10 persons for 24 h. Skin reactions were observed for 2 days.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dibutyl adipate
EC Number:
203-350-4
EC Name:
Dibutyl adipate
Cas Number:
105-99-7
Molecular formula:
C14H26O4
IUPAC Name:
1,6-dibutyl hexanedioate
Details on test material:
- Name of test material (as cited in study report): di-n-butyl adipate
- Physical state: practically odorless, oily liquid with a very low viscosity
- Analytical purity: no data

Method

Type of population:
not specified
Subjects:
- Number of subjects exposed. 10
Ethical approval:
not specified
Route of exposure:
dermal
Reason of exposure:
intentional
Exposure assessment:
estimated
Details on exposure:
TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Type of application: semiocclusive
- Description of patch: plaster
- Concentrations: undiluted
Examinations:
skin reactions determined

Results and discussion

Clinical signs:
During this study no skin reactions were noticeable after 24 hours exposure to the skin.

Applicant's summary and conclusion