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EC number: 208-011-4 | CAS number: 505-52-2
Groups of 10 male Wistar rats received a singel dose of 5, 12.5, or 25 mg dodecanedioic acid by gastric intubation.
In a second experiment ³H-labelled dodecanedioic acid was administered.
Absorption was complete, and excretion was independent of dosage in rats. About 1.6% of C12 were excreted in the urine over a period of 5 days. No dodecanedioic acid was recovered from faeces. The serum concentration and the urinary excretion of the diacids reached a maximum at the second day after the oral dose. The dicarboxylic acids found in serum and urine were 2, 4, or 6 carbon atoms shorter than the corresponding administered diacid. This indicates that there was beta-oxidation of the ingested diacids to some extent. The administration of [10,11-³H]dodecandioic acid confirmed the occurrence of beta-oxidation, and led to elucidation of the fate of the ingested diacids that were not excreted as such in the urine.
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