Registration Dossier
Registration Dossier
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EC number: 426-040-2 | CAS number: 25713-60-4 SR-245
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
3 in vitro studies were performed to assess the mutagenicity potential of FR-245:
Ames test: The substance was found to be not mutagenic in the Salmonella typhimurium reverse mutation assay.
Chromosome aberration: This substance was found to be not clastogenic in human lymphocytes.
In Virto mammalian gene mutation test: This substance was found to be not mutagenic in the mouse lymphoma L5178Y test system.
Further to the results of these studies it can be concluded that FR-245 is not mutagenic.
Short description of key information:
Reverse mutation assay Ämes test using Salmonella Typhimurium.
Chromosome aberration test in human lymphocytes.
In Vitro mammalian gene mutation test in mouse lymphoma test system.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The substance is not mutagenic.
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