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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

3 in vitro studies were performed to assess the mutagenicity potential of FR-245:

Ames test: The substance was found to be not mutagenic in the Salmonella typhimurium reverse mutation assay.

Chromosome aberration: This substance was found to be not clastogenic in human lymphocytes.

In Virto mammalian gene mutation test: This substance was found to be not mutagenic in the mouse lymphoma L5178Y test system.

Further to the results of these studies it can be concluded that FR-245 is not mutagenic.

Short description of key information:
Reverse mutation assay Ämes test using Salmonella Typhimurium.
Chromosome aberration test in human lymphocytes.
In Vitro mammalian gene mutation test in mouse lymphoma test system.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The substance is not mutagenic.