Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute skin irritation to the rabbit
Acute Eye irritation to the rabbit

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Acute irritation studies were performed on the skin and eye of rabbits.

Skin irritation/corrosion: No skin irritation was caused by 4 hours exposure to FR-245.

Eye irritation: Instillation of FR-245 resulted in irritation of the conjunctivae, which consisted of redness and/or chemosis. The irritation had completely resolved within 48 hours in all animals.

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

Based on the experimental results of the Acute skin and eye irritation studies and according to the EEC criteria for classification and labelling requirements for dangerous substances and preparations (Guidelines in Commission Directive 93/21/EEC, 27th April 1993), FR-245 does not have to be classified for skin or eye irritation and has no obligatory labelling requirement for skin irritation or eye irritation.