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EC number: 221-338-7 | CAS number: 3069-40-7
The ECHA Committee for Risk Assessment (RAC) issued an opinion on methanol (ECHA/RAC/RESO-0000006324-78-01/F; ECHA, 2015). In this opinion, a DNEL for short-term oral exposures was derived based on the minimal oral methanol dose related to severe ocular toxicity; LOAEL = 0.26 g/kg bw. An assessment factor of 3 was applied to this LOAEL to derive a oral short-term systemic DNEL of 0.088 g/kg bw (88 mg/kg bw).
The oral LOAEL is used as the dose descriptor starting point for derivation of the inhalation short-term DNEL:
The REACH standard daily inhalation volume for humans is 20 m³/person/day.
To convert this daily volume to a 15 minute volume: 20/(24 x 4) = 0.2 m³/person/15 minutes.
The DNEL of 88 mg/kg bw is equivalent to 5280 mg/person (assuming a body weight of 60 kg)
It follows therefore, that to acheive a dose of 5280 mg/person during 15 minutes of exposure, the inhaled
concentration would need to be 26400 mg/m³.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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