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EC number: 221-111-2 | CAS number: 3006-86-8
Cyclohexylidenebis[tert-butyl]peroxide was tested in the Buehler test with guinea pigs according to OECD guideline no. 406. A 50 % w/v concentration of the test item, in Squibb mineral oil was chosen for occlusive epidermal induction of the test group. This level was chosen as the highest concentration causing no greater than mild to moderate primary irritation. Undiluted Squibb mineral oil was utilized at induction for the vehicle control group. The procedure was repeated at the same site once every seven days for fourteen days for a total of three approximate six-hour exposures.
A 50 % w/v concentration of cyclohexylidenebis[tert-butyl]peroxide, in Squibb mineral oil was chosen for epidermal application at primary challenge for the test group and the vehicle control group. This level was chosen as the highest concentration causing no more than slight primary irritation.
Following primary challenge using cyclohexylidenebis[tert-butyl]peroxide, as a 50 % w/v formulation in Squibb mineral oil, the incidence of grade 1 responses in the test group (9 of 20) was compared to that of the vehicle control group (4 of 10). The incidence and severity of these responses in the test group were essentially comparable to those produced by the vehicle control group indicating that sensitization had not been induced.
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