Registration Dossier
Registration Dossier
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EC number: 203-197-3 | CAS number: 104-38-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Remarks:
- However was subject to Quality Assurance
Test material
- Reference substance name:
- 2,2'-p-phenylenedioxydiethanol
- EC Number:
- 203-197-3
- EC Name:
- 2,2'-p-phenylenedioxydiethanol
- Cas Number:
- 104-38-1
- Molecular formula:
- C10H14O4
- IUPAC Name:
- 2,2'-[1,4-phenylenebis(oxy)]diethanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100mg
- Duration of treatment / exposure:
- Not applicable
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6 animals (3 washed and 3 unwashed)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: Not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: The study report only reports the conjunctival effects as "slight". Thus it is not possible to provide the actual scores.
- Irritant / corrosive response data:
- In unwashed eyes signs of slight irritation consisted of moderate erythema (3/3) and slight oedema (1/3) of the nictitating membranes. All effects were fully reversible by Day 7.
Any other information on results incl. tables
The report does not provide quantitative eye scoring data.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria (Reg 1272/2008) are not met
- Conclusions:
- HQEE was slightly irritating to rabbit eye
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