Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
However was subject to Quality Assurance
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-p-phenylenedioxydiethanol
EC Number:
203-197-3
EC Name:
2,2'-p-phenylenedioxydiethanol
Cas Number:
104-38-1
Molecular formula:
C10H14O4
IUPAC Name:
2,2'-[1,4-phenylenebis(oxy)]diethanol

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: 0.5% aqueous guar gum
Doses:
5000mg/kg
No. of animals per sex per dose:
5 males and 5 females

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
None
Clinical signs:
other: None observed
Gross pathology:
No treatment related changes observed

Applicant's summary and conclusion

Interpretation of results:
other: CLP criteria (Reg 1272/2008) are not met
Conclusions:
The oral oral LD50 >5000 mg/kg to rats.