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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report Date:
1966

Materials and methods

Principles of method if other than guideline:
BASF test
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 2-Methylimidazol

Test animals

Species:
mouse
Strain:
other: Kisslegg
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
200, 250, 320, 400, 800 and 1600 mg/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1, 24 and 48 hours and day 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 350 mg/kg bw
Based on:
test mat.
Mortality:
200 and 250 mg/kg group: none of the animals died
320 mg/kg group: 1/10 animals died
400 mg/kg group: 9/10 animals died
800 and 1600 mg/kg group: all/10 animals died
Clinical signs:
Junmping cramps, morphed tails, dyspnoea and lying on the stomach
Body weight:
Normal body weight gain
Gross pathology:
Substance remaining in and agglutination of the abdominal cavity

Applicant's summary and conclusion