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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Testing is not scientifically justified as this substance is hydrolytically unstable and the decomposition products have a low potential for aquatic bioaccumulation and a low potential to cross biological membranes. Acute toxicity (96-h LC50) of the main decomposition product n-butanol is used as a key value.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 825 mg/L

Additional information

When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than n-butanol and hydrated titanium dioxide (half-life < 2 hours, Brekelmans 2013). The organic decomposition product n-butanol is readily biodegradable and not persistent based on the log Kow value of 0.84. The CSA indicates that toxicity of this substance is similar to the main degradation product n-butanol.

Key studies (short-term toxicity to daphnia and algae) conducted for the analogue category member (titanium tetraisopropanolate CAS 546-68-9) justify that these organometallic titanates hydrolyse during toxicity testing and the aquatic toxicity is similar to the alcohol released in water. Category and read-across justifications are presented in the annexes of the CSR. Therefore, and for reasons of animal welfare, a short-term toxicity study on fish is unjustified, and the key value for CSA is obtained from the studies conducted for n-butanol.

According to Veith et al. (1983), 96-h freshwater LC50 (mortality) of n-butanol to Pimephales promelas is 1740 mg/L based on measured concentrations. According to Mattson et al. (1976), the 96-h freshwater LC50 (mortality) of n-butanol to Pimephales promelas is 1910 mg/l at Lake Superior water and 1910 at reconstructed water, respectively. The study by Bengtsson et al. (1984) reported that the 96-h brackish water LC50 (mortality) of butan-1-ol to Alburnus alburnus is 2300 mg/l.

Based on these studies it was safe to conclude that the target substance is not toxic to fish and the studies on the degradation product (n-butanol) are reliable for C&L purposes. Based on the weight of evidence, the average of two results on P.promelas (1825 mg/l) in freshwater was selected as a key value for CSA.