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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

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Description of key information

Hydrolytically unstable as per OECD 111. The half-life time of the substance is <2 hours at 25 deg. C at pH 4, 7 and pH 9.

Key value for chemical safety assessment

Half-life for hydrolysis:
2 h
at the temperature of:
25 °C

Additional information

The key study was performed by using OECD 111 in accordance with GLP. However, as the substance is highly hydrolytically unstable it was not possible to perform the test as outlined in the guidelines. In order to obtain as much information on hydrolysis as possible, an alternative test was designed. The hydrolytic stability was tested in buffered aqueous solutions at pH 4.0, 7.0, and 9.0 at 25°C for 9 hours. The progress of the hydrolysis was followed by monitoring the main degradation product; n-butanol. Additionally, the formation of a white precipitation was observed during the hydrolysis study. This is due to the formation of the insoluble titanium oxides.No other degradation products were identified.

The response of the hydrolysis product n-butanol was > 98% (area). In the chromatograms, small additional peaks were observed at 3.05 minutes (at pH 7 and 9), 3.15 minutes (at pH 7), 10.11 minutes (at pH 9), all ≤ 1% at the specific mass fragments monitored. The additional peaks might derive from impurities in the test substance and/or hydrolysis products. To achieve sufficient sensitivity for the analysis of the identified hydrolysis product, selected ion monitoring was used as detection method. Therefore it was not possible to obtain accurate information on the mass fraction of the unknown peaks or to record their entire mass spectrum, and hence it was not possible to identify these additional peaks.

The results of this study are considered reliable to be used for C&L purposes to conclude this substance to be hydrolytically unstable releasing only n-butanol and hydrated titanium dioxide when in contact with water. Based on the results this substance can be considered as rapidly degradable.

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