Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-548-6 | CAS number: 2807-30-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
The subject chemical was not a selective developmental toxicant in either rats or rabbits.
Effect on developmental toxicity: via inhalation route
- Dose descriptor:
- NOAEC
- 1 733 mg/m³
Additional information
The subject chemical was not a developmental toxicant in pregnant rats exposed for 6 hours/day at concentrations as high as 400 ppm on gestation days 6 through 15. Common variations in certain skeletal elements and incidence of supernumerary ribs were increased at maternally toxic dose levels. The NOEL for teratogenicity was 400 ppm. Similarly, no significant developmental toxicity was recorded in pregnant rabbits exposed by inhalation for 6 hours/day at concentrations as high as 500 ppm on gestation days 6 through 15. None of the incidences of malformations noted were statistically significantly different from control values. The NOEL for teratogenicity was 500 ppm.
Justification for classification or non-classification
The surrogate test material, 2 -butoxyethanol, was not a selective reproductive toxicant in mice at a dose level of 720 mg/kg bwt/day in a 2 -generation study using a continuous breeding protocol. In sub-chronic and sub-acute inhalation studies in rats, the subject chemical had no effects on the reproductive organs. The subject chemical was also not a selective developmental toxicant in either rats or rabbits exposed by inhalation. Based on the evidence presented, the subject chemical would not be classified for Reproductive Toxicity according to Directive 67/548/EEC, EU CLP (Regulation (EC) No. 1272/2008, and UN GHS. Similarly, based on minimal effects (variations in ossification and supernumerary ribs) noted in the presence of maternal effects, the subject chemical is not classified for Developmental Toxicity according to Directive 67/548/EEC, EU CLP (Regulation (EC) No. 1272/2008, and UN GHS
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
