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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 220-548-6 | CAS number: 2807-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
The subject chemical was not a selective developmental toxicant in either rats or rabbits.
Effect on developmental toxicity: via inhalation route
- Dose descriptor:
- NOAEC
- 1 733 mg/m³
Additional information
The subject chemical was not a developmental toxicant in pregnant rats exposed for 6 hours/day at concentrations as high as 400 ppm on gestation days 6 through 15. Common variations in certain skeletal elements and incidence of supernumerary ribs were increased at maternally toxic dose levels. The NOEL for teratogenicity was 400 ppm. Similarly, no significant developmental toxicity was recorded in pregnant rabbits exposed by inhalation for 6 hours/day at concentrations as high as 500 ppm on gestation days 6 through 15. None of the incidences of malformations noted were statistically significantly different from control values. The NOEL for teratogenicity was 500 ppm.
Justification for classification or non-classification
The surrogate test material, 2 -butoxyethanol, was not a selective reproductive toxicant in mice at a dose level of 720 mg/kg bwt/day in a 2 -generation study using a continuous breeding protocol. In sub-chronic and sub-acute inhalation studies in rats, the subject chemical had no effects on the reproductive organs. The subject chemical was also not a selective developmental toxicant in either rats or rabbits exposed by inhalation. Based on the evidence presented, the subject chemical would not be classified for Reproductive Toxicity according to Directive 67/548/EEC, EU CLP (Regulation (EC) No. 1272/2008, and UN GHS. Similarly, based on minimal effects (variations in ossification and supernumerary ribs) noted in the presence of maternal effects, the subject chemical is not classified for Developmental Toxicity according to Directive 67/548/EEC, EU CLP (Regulation (EC) No. 1272/2008, and UN GHS
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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