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Diss Factsheets
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EC number: 220-548-6 | CAS number: 2807-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1959
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was applied undiluted to the ear, and shaven intact and abraded skin of white rabbits. The intact and abraded areas are covered with a cotton patch then bandaged to hold the material in constant contact with the skin. Each working day fresh material was applied. In this study 2 applications were conducted.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(propyloxy)ethanol
- EC Number:
- 220-548-6
- EC Name:
- 2-(propyloxy)ethanol
- Cas Number:
- 2807-30-9
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 2-(propyloxy)ethanol
- Details on test material:
- Test material: Ethylene glycol n-propyl ether
Source: Ethylene Research Laboratory, The Dow Chemical Company
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Body weight 2.68 kg
Test system
- Type of coverage:
- other: Ear- open, belly- intact and abraded skin both covered
- Preparation of test site:
- other: shaved , intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- No data
- Duration of treatment / exposure:
- 2 single applications to the ear and belly (intact and abraded)
- Observation period:
- Typically up to 1 week after completing the applications.
- Number of animals:
- 1
- Details on study design:
- The test material was applied undiluted to the ear, and shaven intact and abraded skin of white rabbits. The intact and abraded areas are covered with a cotton patch then bandaged to hold the material in constant contact with the skin. Each working day fresh material was applied. In this study 2 applications were conducted.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 1
- Max. score:
- 6
- Remarks on result:
- other: Score for ear and belly (intact and abraded)
- Irritation parameter:
- other: hyperemia
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 1
- Max. score:
- 6
- Remarks on result:
- other: Ear
- Irritation parameter:
- other: hyperemia
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 6
- Remarks on result:
- other: Belly (intact and abraded)
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 1
- Max. score:
- 6
- Remarks on result:
- other: Ear
- Irritation parameter:
- other: necrosis
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 6
- Remarks on result:
- other: Belly (intact and abraded)
- Irritation parameter:
- other: exfoliation
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 6
- Remarks on result:
- other: Ear
- Irritation parameter:
- other: exfoliation
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 1
- Max. score:
- 6
- Remarks on result:
- other: Belly (intact and abraded)
- Irritation parameter:
- other: scab and scar
- Basis:
- animal #1
- Time point:
- other: 24 hour
- Score:
- 2
- Max. score:
- 6
- Remarks on result:
- other: Belly (abraded)
- Irritant / corrosive response data:
- No irritation was observed on the ear or belly (intact and abraded).
- Other effects:
- The rabbit died after the second application, probably due to systemic injury as a result of absorption through the skin. Observations consisting of bloody urine and burned-dark green were noted. Animal appeared to be a bit nervous.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- The material should present no problem from skin irritation as a result of a single prolonged exposure to either intact or abraded skin. However, range finding tests indicate that the material is absorbed through the skin and is capable of producing serious internal injury. According to the EU CLP regulations (GHS Criteria), the substance would be not be classified.
- Executive summary:
2 single applications of Ethylene glycol n-propyl ether to the ear and belly (intact and abraded) of rabbit were evaluated and no irritation was observed on the ear or belly (intact and abraded). According to the EU CLP regulations (GHS Criteria), the substance would be not be classified.
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