Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The subject chemical failed to produce neurological effects at a vapor concentration of 400 ppm (1733 mg/m3), the highest level tested.

Key value for chemical safety assessment

Effect on neurotoxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
1 733 mg/m³

Additional information

Groups of 10 male and female rats were exposed to the subject chemcial at concentrations of 0, 100, 200 and 400 ppm for 6 hours/day, 5 days/week for 14 weeks. Clinical signs and body weight gains were recorded. Neurological analyses included a Functional Observational Battery (FOB), conducted 4 days prior to exposure and at 4, 10, 32, 60 and 95 days after the initial exposure. Forelimb and hind limb grip strengths were also quantitatively evaluated. Central nervous system (CNS) and peripheral nervous system (PNS) tissues were examined histopathologically. No neurological defects were noted in the FOB analyses. Neuropathological lesions were not observed either in the CNS or PNS of exposed rats.

Justification for classification or non-classification

Based on the results of sub-chronic inhalation toxicity testing in rats, the subject chemical would not be classified for “neurotoxicity” according to Directive 67/548/EEC, EU CLP (Regulation (EC) No. 1272/2008 and UN GHS.