Registration Dossier
Registration Dossier
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EC number: 220-548-6 | CAS number: 2807-30-9
Neurotoxicity
Administrative data
Description of key information
The subject chemical failed to produce neurological effects at a vapor concentration of 400 ppm (1733 mg/m3), the highest level tested.
Key value for chemical safety assessment
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 1 733 mg/m³
Additional information
Groups of 10 male and female rats were exposed to the subject chemcial at concentrations of 0, 100, 200 and 400 ppm for 6 hours/day, 5 days/week for 14 weeks. Clinical signs and body weight gains were recorded. Neurological analyses included a Functional Observational Battery (FOB), conducted 4 days prior to exposure and at 4, 10, 32, 60 and 95 days after the initial exposure. Forelimb and hind limb grip strengths were also quantitatively evaluated. Central nervous system (CNS) and peripheral nervous system (PNS) tissues were examined histopathologically. No neurological defects were noted in the FOB analyses. Neuropathological lesions were not observed either in the CNS or PNS of exposed rats.
Justification for classification or non-classification
Based on the results of sub-chronic inhalation toxicity testing in rats, the subject chemical would not be classified for “neurotoxicity” according to Directive 67/548/EEC, EU CLP (Regulation (EC) No. 1272/2008 and UN GHS.
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