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Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from experemental study report

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS NUMBER : WB6475000
Author:
Bandman A.L. et al.,
Year:
2012
Bibliographic source:
RTECS; "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989. Volume(issue)/page/year: -,404,1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity in mouse.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium iodide
EC Number:
231-679-3
EC Name:
Sodium iodide
Cas Number:
7681-82-5
Molecular formula:
INa
IUPAC Name:
sodium iodide
Test material form:
solid: crystalline
Details on test material:
- Substance type: Inorganic
- Physical state: solid

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
2 h
Remarks on duration:
not specified
Concentrations:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LCLo
Effect level:
50 000 mg/m³ air
Based on:
test mat.
Exp. duration:
2 h
Mortality:
not specified
Clinical signs:
other: not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
Inhalation toxicity (LCLo value) of test chemical was examined for 2 hrs. in mouse at a dose concentration of 50000 mg/m3.Hence the LC50 value is >50000 mg/m3.This value suggests that the test chemical is non toxic to mouse by the inhalation route.
Executive summary:

Acute inhalation toxicity study (LCLo) of test chemical was conducted on mouse at the dose concentration of 50000mg/m3 for 2 hours. All animals were maintained under close observation for recording toxic signs and time of death. Therefore, LC50 value was considered to be >50000mg/m3, when mice were treated with test chemical. This value suggests that the test chemical is non toxic to mouse by the inhalation route.