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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Further information is included in the detailed justification for read-across in the endpoint summary “Physical and chemical properties”.

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar physicochemical properties because they share structural similarities with common functional groups: quaternary amines, and fatty acid chains with comparable length and degree of saturation.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Further information is included in the detailed justification for read-across in the endpoint summary “Physical and chemical properties”.

3. ANALOGUE APPROACH JUSTIFICATION
Further information is included in the detailed justification for read-across in the endpoint summary “Physical and chemical properties”.

4. DATA MATRIX
Further information is included in the detailed justification for read-across in the endpoint summary “Physical and chemical properties”.
Reason / purpose for cross-reference:
read-across source
Type:
log Pow
Partition coefficient:
3.8

Description of key information

technically not feasible (in  the EU RAR 'DODMAC' (CAS 107 -64 -2), a chemical structurally similar to MDEA-Esterquat C16-18 and C18 unsatd. , a measured log Kow=3.8 is reported)

Key value for chemical safety assessment

Log Kow (Log Pow):
3.8
at the temperature of:
20 °C

Additional information

According to REACH regulation (Annex XI, 2.), the study does not need to be done if it is technically not feasible: The determination of the n-octanol/water partition coefficient log Kow is technically not feasible due to the surface-active properties of the test substance.

According to EU RAR Dimethyl dioctadecylammonium chloride (2002), as DODMAC is a surface-active substance, the log Kow value can not be used to derive the environmental distribution constants. Instead of this, experimentally determined figures (BCF, Koc) are used. For justification for read-across pleae refer to Endpoint summary "Physical and chemical properties".