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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

water solubility
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
December, 2012 to April, 2013
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Performed according to GLP standard
Reason / purpose for cross-reference:
reference to same study

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guidelineopen allclose all
according to guideline
OECD Guideline 105 (Water Solubility)
according to guideline
EU Method A.6 (Water Solubility)
Principles of method if other than guideline:
An attempt was made to determine the water solubility of cocoa powder using OECD method 105 (Regulation 440/2008/EEC method A6) under appropriate GLPs, however, it was not possible to develop a calibration line, or to obtain a TOC on the substance “cocoa powder”, only potentially on some components. The water solubility of cocoa powder was therefore assessed using a standard gravimetric method (results tables provided in section below).
GLP compliance:
Type of method:
other: Standard Gravimetric Method

Test material

Constituent 1
Reference substance name:
Cocoa powder
Cocoa powder
Test material form:
solid: particulate/powder
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Cocoa powder (22.5% lipids)
- Substance type: UVCB
- Physical state: Powder
- Analytical purity: No data
- Composition of test material, percentage of components: No data
- Purity test date: No data
- Lot/batch No.:BHF092012
- Expiration date of the lot/batch: No data
- Stability under test conditions:
- Storage condition of test material:
- Other:

Results and discussion

Water solubility
20 °C
Remarks on result:
other: pH not determined

Applicant's summary and conclusion

Executive summary:

The objective of this study was to evaluate the water solubility of the test substance, cocoa powder (20 -24%). At all dilutions only a limited proportion of the substance demonstrated solubility in water. The substance is multi-component, with the components having different solubilities and ca 70-80% of the components insoluble in water. It has therefore not been possible to determine a meaningful solubility for the substance.