Registration Dossier
Registration Dossier
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EC number: 305-748-4 | CAS number: 95009-22-6
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- December, 2012 to April, 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Performed according to GLP standard
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Principles of method if other than guideline:
- An attempt was made to determine the water solubility of cocoa powder using OECD method 105 (Regulation 440/2008/EEC method A6) under appropriate GLPs, however, it was not possible to develop a calibration line, or to obtain a TOC on the substance “cocoa powder”, only potentially on some components. The water solubility of cocoa powder was therefore assessed using a standard gravimetric method (results tables provided in section below).
- GLP compliance:
- yes
- Type of method:
- other: Standard Gravimetric Method
Test material
- Reference substance name:
- Cocoa powder
- IUPAC Name:
- Cocoa powder
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Cocoa powder (22.5% lipids)
- Substance type: UVCB
- Physical state: Powder
- Analytical purity: No data
- Composition of test material, percentage of components: No data
- Purity test date: No data
- Lot/batch No.:BHF092012
- Expiration date of the lot/batch: No data
- Stability under test conditions:
- Storage condition of test material:
- Other:
Constituent 1
Results and discussion
Water solubility
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not determined
Applicant's summary and conclusion
- Executive summary:
The objective of this study was to evaluate the water solubility of the test substance, cocoa powder (20 -24%). At all dilutions only a limited proportion of the substance demonstrated solubility in water. The substance is multi-component, with the components having different solubilities and ca 70-80% of the components insoluble in water. It has therefore not been possible to determine a meaningful solubility for the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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