Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2007-01-12 to 2007-01-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes
Type of method:
column elution method
Key result
Water solubility:
< 0.01 mg/L
Incubation duration:
46 - 52.2 h
Temp.:
20 °C
pH:
6.7
Details on results:
Preliminary Visual Estimation of the Water Solubility
Increasing water amounts were added stepwise to different amounts of the test item. The preliminary visual experiments showed that the water solubility of the test item is below 10 mg/L. Therefore the water solubility had to be determined by the "column elution method".

Column 1:

Rotation period of the fraction accumulator: 90 min per fraction

Average fraction volume: 16.8 mL

Flow rate: between 11.0 mL/h and 11.3 mL/h

Duration of sampling: about 52.5 h (35 fractions)

Column 2:

Rotation period of the fraction accumulator: 45 min per fraction

Average fraction volume: 16.0 mL

Flow rate: between 20.7 mL/h and 21.3 mL/h

Duration of sampling: about 52.5 h (70 fractions)

Column 3 (blank):

Rotation period of the fraction accumulator: 45 min per fraction

Average fraction volume: 15.9 mL

Flow rate: between 20.7 mL/h and 21.3 mL/h

Duration of sampling: about 46 h (61 fractions)

Column-elution method: Column 1

Fraction
no.

V
in mL

pH

water solubility
in mg/L

25

16.5

6.7

<0.01

26

16.5

6.9

<0.01

27

16.5

6.7

<0.01

28

16.5

6.7

<0.01

29

16.5

6.6

<0.01

According to the guideline the run can be stopped if the concentrations of five fractions do not differ more than ± 30 % without any raising or descending tendency. The content of test item in every fraction is below the detection limit.

Column-elution method: Column 2

Fraction
no.

V

in mL

pH

water solubility
in mg/L

57

16.0

6.7

<0.01

58

16.0

6.6

<0.01

59

16.0

6.6

<0.01

60

16.0

6.4

<0.01

61

16.0

6.5

<0.01

According to the guideline the run can be stopped if the concentrations of five fractions do not differ more than ± 30 % without any raising or descending tendency. The content of test item in every fraction is below the detection limit.

Column-elution method: Column 3 (blank) 

Fraction
no.

V

in mL

pH

water solubility
in mg/L

35

16.0

6.6

<0.01

36

16.0

6.6

<0.01

37

16.0

6.5

<0.01

38

16.0

6.3

<0.01

39

16.0

6.5

<0.01

According to the guideline, the data of the fractions 1 to 5 were not taken into account for the following evaluation. The values for the water solubility were calculated from the fractions 25 to 29 for column 1, from the fractions 57 to 61 for column 2, from the fractions 35 to 39 for column 3.

All other fractions were discarded.

Result column 1:

Evaluation of the fractions 25 to 29:

The water solubility was found to be: < 0.01 mg/L (without correction of the purity)

Result column 2:

Evaluation of the fractions 57 to 61:

The water solubility was found to be: < 0.01 mg/L (without correction of the purity)

Result column 3:

Evaluation of the fractions 35 to 39: The blank concentration was found to be < 0.01 mg/L.

The water solubility of the test item at a temperature of 20°C was determined to (without correction for the purity):< 0.01 mg/L

Conclusions:
The water solubility of the test item was determined to be < 0.01 mg/L at 20 °C.
Executive summary:

The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis.Two identical samples were prepared, one of them was exposed to a flow rate of 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). After measurement of the volume, pH and temperature, the fractions were subjected to HPLC analysis. Another experiment was performed according to this procedure (flow rate 25.0 mL/h) but without test item ("blank" = column 3).

The water solubility of the test item at a temperature of 20 °C was determined (without correction for the purity) to be < 0.01 mg/L.

Description of key information

The water solubility of the test item was determined to be < 0.01 mg/L at 20 °C.

Key value for chemical safety assessment

Additional information

The water solubility was determined according to OECD 105 using the column elution method with HPLC analysis.Two identical samples were prepared, one of them was exposed to a flow rate of 12.5 mL/h (column 1), the other one to 25.0 mL/h (column 2). After measurement of the volume, pH and temperature, the fractions were subjected to HPLC analysis.Another experiment was performed according to this procedure (flow rate 25.0 mL/h) but without test item ("blank" = column 3).

The water solubility of the test item at a temperature of 20 °C was determined (without correction for the purity) to be < 0.01 mg/L (reference 4.8-1).