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EC number: 249-949-4 | CAS number: 29911-27-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to OECD TG 401 and EU Method B.1 and in accordance with the Principles of GLP.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1-(1-methyl-2-propoxyethoxy)propan-2-ol
- EC Number:
- 249-949-4
- EC Name:
- 1-(1-methyl-2-propoxyethoxy)propan-2-ol
- Cas Number:
- 29911-27-1
- Molecular formula:
- C9H20O3
- IUPAC Name:
- 1-(1-methyl-2-propoxyethoxy)propan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Dowanol ® DPnP (Dipropylene glycol n-propylether)
- Physical state: Clear liquid
- Analytical purity: > 99%
- Lot/batch No.: MM 940619
- Stability under test conditions: Stable
- Storage condition of test material: At room temperature in the dark
- Density: 0.89 g/ml
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were obtained from Charles River, Germany. They were approximately 7 weeks old at start of treatment. Body weights of animals used in the study were within +/- 20% of the sex mean.
Animals were housed in a room maintained at 21 degrees C and a relative humidity of 50%. Fluctuations from these conditions occurred, but did not affect study integrity. The lighting cycle was 12 hours light/12 hour dark, and there were 15 air changes/hour.
Animals were housed 5/sex/cage in polycarbonate cages containing purified sawdust bedding material, and were allowed free access to standard pelleted laboratory animal diet (Carfil Quality BVBA, Oud-Turnhout, Belgium) and tap water (with the exception that food was withheld overnight prior to dosing until 3-4 hours after dosing). Animals were acclimated at least 5 days before treatment.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Five animals/sex dosed once, on Day 1
- Doses:
- 2000 mg/kg body weight (2.247 ml/kg)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Animals were observed twice daily for mortality and at periodic intervals on Day 1 and once daily thereafter for clinical signs. All animals surviving to the end of the 15 day observation period were euthanized and subjected to a gross necropsy.
- Statistics:
- No statistical analyses was perrformed
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One male died within 1 hour of treatment.
- Clinical signs:
- other: Lethargy, uncoordinated movements and/or hunched posture in all animals until Day 2. These symptoms had disappeared in all surviving by day 2. Chromodacryorrhea was observed in one male from Day 1 to Day 6.
- Gross pathology:
- No abnormalities
- Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value of Dowanol ® DPnP (Dipropylene glycol n-propylether) in rats (both sexes) was established as greater than 2000 mg/kg bw. and hence based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, Dowanol ® DPnP (Dipropylene glycol n-propylether) will not be classified.
- Executive summary:
This study was carried out in accordance with OECD Guideline No. 401, "Acute Oral Toxicity" and EEC Directive 92/69/EEC, Part B.1, "Acute Toxicity-Oral” to evaluate the acute oral toxicity potential of Dowanol ® DPnP (Dipropylene glycol n-propylether).
Dowanol ® DPnP (Dipropylene glycol n-propylether) was administered by oral gavage to five rats of each sex per group, at 2000 mg/kg body weight. Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed on the day of death or at the end o f the experimental period (day 15). One male died on day 1. Lethargy, uncoordinated movements and/or hunched posture were observed in the animals on day 1.Chromodacryorrhoea was observed in one male from day 1 until day 6. Body weight gain shown by the animals over the study period was considered to be normal. No abnormalities were found in the animals at macroscopic post mortem examination.
The oral LD50 value of Dowanol ® DPnP (Dipropylene glycol n-propylether) in rats was established as exceeding 2000 mg/kg body weight and hence based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, Dowanol ® DPnP (Dipropylene glycol n-propylether) will not be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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