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EC number: 232-619-9
CAS number: 9001-62-1
batch PPW 1798 was tested in rats for effects on fertility and general
reproductive performance over 2 generations of animals.
female rats were randomized into 3 treatment groups and one control
group, each group containing 24 males and 24 females. The animals
received diet containing the following constant concentration of lipase:
% lipase by Weight in the Diet
males received treated diets 10 weeks prior to mating, the F0 females
for 2½ weeks prior to mating. Treatment continued for both sexes
throughout mating, gestation and lactation. The F0 animals were then
killed and necropsied. The F1 animals which were selected for rearing to
maturity and breeding then received treated diet for approximately 10
weeks, prior to mating at 13-14 weeks of age. Treatment continued
throughout mating, gestation and lactation, following which the F1
animals and their F2 litters were killed, the former being necropsied.
for clinical signs for toxicology, body weight performance, food
consumption and reproductive performance were collected for the F0 and
F1 generations. Body weight and clinical observations, including
survival, were collected for the F2 generation until the time of
termination just after Day 4 of lactation.
At 5% and
1.5% lipase in the diet, there were very slight enhancement of F0 female
body weight performance, such that after 9 weeks of treatment, the
animals weighed 6-8% more than controls. No such effect was observed
during the growth to maturity of the F1 animals.
no effect of treatment with the test material on either F0 or F1
fertility and general reproductive performance, at exposure levels of up
to 5% lipase by weight in the diet.
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