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Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is predicted using QSAR Toolbox version 2.3.
GLP compliance:
no
Type of study:
Draize test
Species:
human
Strain:
other: not applicable
Sex:
male/female
Route:
epicutaneous, occlusive
Vehicle:
no data
Concentration / amount:
no data
Route:
other: no data
Vehicle:
no data
Concentration / amount:
no data
No. of animals per dose:
no data
Positive control substance(s):
not specified
Reading:
1st reading
Group:
test group
Clinical observations:
The substance is found to be sensitizing to skin of humans
Remarks on result:
other: Reading: 1st reading. Group: test group. Clinical observations: The substance is found to be sensitizing to skin of humans.

The prediction was based on dataset comprised from the following descriptors: "Skin Sensitisation"
Estimation method: Taking highest mode value from the 5 nearest neighbours


("a" and "b" )

Domain logical expression index: "a"

Parametric boundary:The target chemical should have a value of log Kow which is >= -7.18

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is <= -7.18

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to the quantitative structure activity relationship model prediction, Calcium iodate was predicted as being sensitizing to the human skin.
Executive summary:
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According to the quantitative structure activity relationship model prediction, Calcium iodate was predicted as being sensitizing to the human skin. This prediction is conclusive but not sufficient for classification of the substance as a skin sensitiser.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Based on studies of target substance Calcium iodate and read across reviewed for skin sensitization from reliable sources having Klimisch rating 2 and 4considering the weight of evidence approach.

 

The summary of the results are presented below

Sr. No

End point

effect

Species

Remark

1

Skin sensitization

sensitizing

Human

Predicted data for target chemical

2

Skin sensitization

not sensitizing

guinea pig

Data is from publication for CAS NO 7681-11-0

 

Based on results summarized in above table for the target chemical Calcium iodate and read across, it can be concluded that the substance is sensitizing to the skin of human since the data is conclusive but not sufficient for classification of the substance as a skin sensitizer.Thus calcium iodate is considered to be not sensitizing to skin as per the criteria of CLP regulation.


Migrated from Short description of key information:
Calcium iodate was predicted as being sensitizing to the human skin. This prediction is conclusive but not sufficient for classification of the substance as a skin sensitiser.

Justification for selection of skin sensitisation endpoint:
According to the quantitative structure activity relationship model prediction, Calcium iodate was predicted as being sensitizing to the human skin.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

According to the quantitative structure activity relationship model prediction, Calcium iodate was predicted as being sensitizing to the human skin. This prediction is conclusive but not sufficient for classification of the substance as a skin sensitiser.