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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Potassium iodate toxic retinopathy: a report of five cases
Author:
Singalavanija A; Ruangvaravate N; Dulayajinda D,
Year:
2000
Bibliographic source:
Retina (Philadelphia, Pa.) (2000), 20(4), 378-83

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
The clinical manifestation , toxic dosage of iodate and ocular changes in humans, who has taken potassium iodate overdose were analysed
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material : Potassium iodate
- Substance type : Inorganic
- Physical state : Solid

Test animals / tissue source

Species:
human
Details on test animals or tissues and environmental conditions:
- Age at study initiation : 22 years
- Weight at study initiation : 45 kg

Test system

Vehicle:
water
Controls:
no
Observation period (in vivo):
3 hrs
Details on study design:
A 22-year-old man had drunk approximately half of the contents (approx 300 ml) of a whiskey bottle . The bottle had contained a concentrated KIO3 solution

Results and discussion

In vivo

Results
Irritation parameter:
other: retinal toxicity
Time point:
other: 3 hrs
Remarks on result:
other: Irritating to eyes
Other effects:
Nausea, vomiting and diarrhea was observed three hrs after ingestion. Two hours later he had blurred vision .Ocular examination showed a visual acuity (VA) of hand motions in both eyes. The fundi showed retinal edema with hypo pigmentation in the macular area. Fundus Fluorescein angiography(FFA) showed extensive RPE window defects in both eyes. The flash ERG showed a marked reduction in amplitude and delayed implicit time of a- and b-waves with all stimuli in both eyes. Flash VEP showed a normal latency and decreased amplitude of P100 in both eyes. Findings from urine examination and blood chemistry were normal.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
From the above case study it is concluded that potassium iodate produce retinal toxicity that damage RPE and photoreceptor cells

Executive summary:

In a case studya 22-year-old man had drunk approximately half of the contents (approx 300 ml) of a whiskey bottle .The bottle had contained a concentrated KIO3 solution. The patient weighed 45 kg, so the approximately oral dose ingested was 187 mg/kg body weight. Three hours after ingesting the solution, he experienced nausea, vomiting and diarrhoea. Two hours later he had blurred vision that he described as “seeing in a fog." Ocular examination showed a visual acuity. The fundi showed retinal edema with hypo pigmentation in the macular area. This shows that potassium iodate produce retinal toxicity that damage RPE and photoreceptor cells.