Registration Dossier
Registration Dossier
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EC number: 232-191-3 | CAS number: 7789-80-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for "Discriminating Dose" read across evaluation for 7758-05-6
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is predicted using QSAR toolbox Version 2.3
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- Potassium iodate
- EC Number:
- 231-831-9
- EC Name:
- Potassium iodate
- Cas Number:
- 7758-05-6
- IUPAC Name:
- potassium iodate
- Details on test material:
- - Name of test material: Potassium iodate
- Molecular formula: HIO3.K
- Molecular weight: 214.02
- Substance type: Inorganic
- Physical state: Solid
- SMILES:O=I(=O)O{-}.K{+}
Constituent 1
Test animals
- Species:
- other: Human
- Strain:
- other: not applicable
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: "Discriminating Dose"
- Effect level:
- 1 300 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: "discriminating dose"
Estimation method: Taking average value from the 5 nearest neighbours
("a"
and "b" )
Domain
logical expression index: "a"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 0.0436
Domain
logical expression index: "b"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 0.0436
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.
- Executive summary:
The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.
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