Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 2.3.0.1132 prediction for "Discriminating Dose" read across evaluation for 7758-05-6
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
QSAR Toolbox version 2.3

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is predicted using QSAR toolbox Version 2.3
GLP compliance:
no
Test type:
fixed dose procedure

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Potassium iodate
- Molecular formula: HIO3.K
- Molecular weight: 214.02
- Substance type: Inorganic
- Physical state: Solid
- SMILES:O=I(=O)O{-}.K{+}

Test animals

Species:
other: Human
Strain:
other: not applicable
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: "Discriminating Dose"
Effect level:
1 300 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: "discriminating dose"
Estimation method: Taking average value from the 5 nearest neighbours


("a" and "b" )

Domain logical expression index: "a"

Parametric boundary:The target chemical should have a value of log Kow which is >= 0.0436

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.0436

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.
Executive summary:

The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.