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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 2.3.0.1132 prediction for LD50 read across evaluation for 7789-80-2
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
QSAR toolbox version 2.3

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Calcium iodate
- Substance type: inorganic
- Physical state: Solid
-SMILES:O=I(=O)O{-}.[Ca]{2+}.O{-}I(=O)=O

Test animals

Species:
mouse
Strain:
Swiss
Sex:
male/female

Administration / exposure

Route of administration:
oral: drinking water
Vehicle:
unchanged (no vehicle)
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
358.667 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours


("a" and "b" )

Domain logical expression index: "a"

Parametric boundary:The target chemical should have a value of log Kow which is >= -7.18

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is <= -7.18

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight.
Executive summary:

The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight. This value suggest that Calcium iodate exhibits acute toxicity in the Category 4 which is relatively non toxic.