Registration Dossier
Registration Dossier
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EC number: 232-191-3 | CAS number: 7789-80-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Conversion of iodate to iodide in vivo and in vitro.
- Author:
- Taurog A. Howells EM, Nachimson HI,
- Year:
- 1 966
- Bibliographic source:
- J Biol Chem, 241:4686–4693.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- No data available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium iodate
- EC Number:
- 231-831-9
- EC Name:
- Potassium iodate
- Cas Number:
- 7758-05-6
- IUPAC Name:
- potassium iodate
- Details on test material:
- - Name of test material : potassium iodate
- Molecular formula : KIO3
- Molecular weight : 214 g/mol
- Substance type : Inorganic
- Physical state : Solid (powder)
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- Rabbits were given doses of 0.750 to 1.0 µg of iodine) intraperitoneally using iodate injection
- Duration and frequency of treatment / exposure:
- No data available
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.750 to 1.0 µg of iodine
- No. of animals per sex per dose / concentration:
- No data available
- Control animals:
- not specified
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Rapid absorption of iodate by the thyroid gland has been reported
- Type:
- distribution
- Results:
- After iodate injection, radioactivity in tissues (as well as in urine) was exclusively in the form of iodide.
- Type:
- metabolism
- Results:
- iodate is quantitatively reduced to iodide by non-enzymatic reactions and thus becomes available to the body as iodide. Therefore, except perhaps for the gsatro-intestinal mucosa, exposure of tissues to iodate might be minimal.
- Type:
- excretion
- Results:
- There are reports suggesting a direct blood-to-intestine excretion route for iodide.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Rapid absorption of iodate by the thyroid gland has been reported
- Details on distribution in tissues:
- After iodate injection, radioactivity in tissues (as well as in urine) was exclusively in the form of iodide.
- Details on excretion:
- There are reports suggesting a direct blood-to-intestine excretion route for iodide
Metabolite characterisation studies
- Metabolites identified:
- no
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- In humans and rats, oral bioavailability of iodine from iodate is virtually equivalent to that from iodide
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
From the information available above, the bio-accumulation potential of potassium iodate appears to be low (except in eye). At much higher doses given intravenously (i.e., above 10 mg/kg), iodate is highly toxic to the retina. Ocular toxicity in humans has occurred only after exposure to doses of 600 to 1200 mg per individual. - Executive summary:
From the information available above, the bio-accumulation potential of potassium iodate appears to be low (except in eye). At much higher doses given intravenously (i.e., above 10 mg/kg), iodate is highly toxic to the retina. Ocular toxicity in humans has occurred only after exposure to doses of 600 to 1200 mg per individual.
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