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EC number: 234-841-1
CAS number: 12036-21-4
Vanadium, as vanadyl sulphate pentahydrate,
was evaluated for its embryotoxic, fetotoxic and teratogenic potential
in Swiss mice. The compound was administered by gavage to pregnant mice
at doses of 0, 37.5, 75 or 150 mg/kg body weight/day on days 6 -15 of
pregnancy. On gestation day 18, all live fetuses were examined for
external, visceral and skeletal malformations and variations.
Maternal toxicity was observed in all
vanadium-treated animals, evidend by reduced weight gain, reduced body
weight on gestation day 18 (corrected for gravid uterine weight) and
decreased absolute liver and kidney weights at 75 and 150 mg/kg body
weight/day. The number of total implants, live and dead fetuses, late
resorptions, sex ratio and post-implantation losses were not
significantly different between the vanadium-treated mice and the
controls. However, there was a significant increase in the number of
early resorptions per litter at all dose levels. Fetotoxicity was
evidend by lower fetal weights and lengths and the presence of
developmental variations. Malformation incidence also increased by
administration of vanadium. Thus, the NOEL for maternal toxicity,
embryo-/fetotoxicity and teratogenicity for vanadyl sulphate
pentahydrate under these test conditions can be expected below 37.5
mg/kg body weight/day in Swiss mice.
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