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EC number: 696-364-9 | CAS number: 133779-11-0
The aim of the study was to determine tissue/organ distribution of14C-Octadecyl diamineafter oral administration in the male rat using quantitative whole-body autoradiography. Specifically: the rats were given 62.5 or 6.25 mg/kg body weight of the test item by gavage, and were killed 1, 4 and 24 hours after the last administration.
Two daily repeated applications in the high dose level with "cold" test item followed by one application of radiolabeled test item on the 3rd day.
Six daily repeated applications in two dose levels with "cold" test item followed by one application of radiolabeled test item on the 7th day.
Generally, the distribution pattern was similar for all animals independent of time points, doses or dose regimens. The highest tissue concentrations of radioactivity were registered in the intestinal mucosa, abdominal lymph nodes, liver, spleen, adrenal cortex, myocardium and brown fat. All other tissues showed low or very low levels of radioactivity.
The labeled diamine seemed to be quite slowly absorbed from the gastrointestinal tract. The blood radioactivity was low and slightly above LOQ for the different doses and dose regimens. Furthermore, for almost all tissues the highest concentration of radioactivity was obtained at 24 hours after the administration.
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