Registration Dossier

Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
endocrine system modulation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Well reported study, no details on test material purity

Data source

Reference
Reference Type:
publication
Title:
Estrogenic Activities of UV Stabilisers Used in Food Contact Plastics and Benzophenone Derivatives Tested by the Yeast Two-Hybrid Assay
Author:
Kawamura Y, Ogawa Y, Nishimura T, Kikuchi Y, Nishikawa J, Nishihara T, Tanamoto K
Year:
2003
Bibliographic source:
J. Health Sci., 49(3), 205-212

Materials and methods

Principles of method if other than guideline:
Estrogenic activity tested by the yeast two-hybrid assay
GLP compliance:
no
Type of method:
in vitro
Endpoint addressed:
not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
Bumetrizole
EC Number:
223-445-4
EC Name:
Bumetrizole
Cas Number:
3896-11-5
Molecular formula:
C17 H18 Cl N3 O
IUPAC Name:
2-tert-butyl-6-(5-chloro-2H-1,2,3-benzotriazol-2-yl)-4-methylphenol
Test material form:
solid
Specific details on test material used for the study:
- Supplier: Tokyo Kasei kogyo Co. (Tokyo, Japan)

Results and discussion

Details on results:
The REC10 was >1.0E-04 M, indicating that the test substance had no estrogenic activity.

Applicant's summary and conclusion