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EC number: 690-920-4 | CAS number: 494799-38-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- methyl 3-cyclopentyl-1-methyl-1H-indole-6-carboxylate
- Cas Number:
- 494799-38-1
- Molecular formula:
- C16 H19 N O2
- IUPAC Name:
- methyl 3-cyclopentyl-1-methyl-1H-indole-6-carboxylate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): CD 6003 XX
- Physical state: powder:
- Analytical purity: 99.7 %
- Lot/batch No.: T1031
- Storage condition of test material: room temperature, ambient humidity and protected from light
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- 7.8, 15.6. 31.3, 62.5, 125.0, 250.0 µg/plate
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
Controls
- Negative solvent / vehicle controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- 2-nitrofluorene
- sodium azide
- methylmethanesulfonate
- other: 2-aminoanthracene
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation);
NUMBER OF REPLICATIONS: 3 - Evaluation criteria:
- S. typhimurium strains TA 1535, TA 1537, TA 98 : An increase in mean revertant numbers to greater or equal to 3x the concurrent vehicle control
mean revertant number or 20, whichever is greater.
S. typhimurium strain TA 100 and E.coli WP2 uvrA :An increase in mean revertant numbers to greater or equal to 2x the concurrent vehicle control
revertant number.
A positive response typically includes a reproducible dose-related significant increase in mean revertant numbers that my be reduced at high dose
levels due to cytotoxicity.
These criteria are guidelines for evaluation and may be modulated by other biological factors that are discussed within the context of the report.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
CD 6003 XX did not induce a significant increase in colony numbers in Salmonella typhimurium strains TA 153, TA 1537, TA 98, TA 100 and
Escherichia coli WP2 uvrA ( pKM101 ) in the presence and absence of a post-mitochondrial fraction (S9 mix) from Aroclor induced rat liver , when
tested up to 250 µg/plate , which was toxic and exceeded the limits of solubility. It is concluded that CD 6003 XX was non-mutagenic under the
conditions of this study. - Executive summary:
The mutagenic potential of CD 6003 XX was investigated in a study with Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and Escherichia coli WP2 uvrA ( pKM101 ).
The test were conducted between October 11,2005 and October 13,2005 using the plate incorporation method in presence and absence of an Aroclor 1254 -induced rat liver preparation and co-factors (S9 mix ) required for mixed function oxidase activity. Each dose level and control was plated triplicate.
The bacteria were treated with 7.8, 15.6. 31.3, 62.5, 125.0 and 250.0 µg/plate of CD 6003 XX in the presence and absence of an activation system.
At the highest dose level, 250 µg/plate, the test article precipitated upon addition to the aqueous agar/bacteria mixture. There was a reduction of colonies, indicative of toxicity, in TA 100 at dose level greater or equal to 62.g µg/plate in the absence of an activation system.There was no evidence of toxicity in the other strains. There was no evidence of a significant increase in the number of colonies in any of the strains, when tested in either the presence and absence of S9 mixture.
CD 6003 XX was non-mutagenic when tested in Salmonella typhimurium strains TA 1535, TA 1537, TA 98, TA 100 and Escherichia coli WP2 uvrA ( pKM101 ) in the presence and absence of an activation system at dose levels up to 250 µg/plate , which was toxic and exceeded the limits of solubility.
It is concluded that CD 6003 XX was non-mutagenic under the conditions of this study.
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