Registration Dossier
Registration Dossier
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EC number: 936-788-6 | CAS number: 1307233-94-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- ethyl 3-{1-[2-(chloromethyl)-1-methyl-1H-1,3-benzodiazol-5-yl]-N-(pyridin-2-yl)formamido}propanoate
- EC Number:
- 936-788-6
- Cas Number:
- 1307233-94-8
- Molecular formula:
- C20 H21 Cl N4 O3
- IUPAC Name:
- ethyl 3-{1-[2-(chloromethyl)-1-methyl-1H-1,3-benzodiazol-5-yl]-N-(pyridin-2-yl)formamido}propanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:WI(Han)
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Hydroxyl Ethyl Cellulose (Natrosol 250) 0.5%
- Doses:
- 300 and 2000mmg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The acute median lethal oral dose (LD50) to rats of BIBR 1048 CBI (Chlorbenzimidazole PD 768) was demonstrated to be between 300 and
2000 mg/kg bodyweight.
BIBR 1048 CBI (Chlorbenzimidazole PD 768) is included in Category 4, according to the Globally Harmonised System (GHS),
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