Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 911-490-9 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.8 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 246 mg/m³
- Explanation for the modification of the dose descriptor starting point:
No specific metabolism expected, thus oral to inhalation extrapolation based on absorption, which is considered 100% for both routes of exposure.
- AF for dose response relationship:
- 1
- Justification:
- Based on derivation of the NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- extrapolation from subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- no correction for caloric demand for inhalation
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance
- AF for intraspecies differences:
- 5
- Justification:
- standard factor for workers
- AF for the quality of the whole database:
- 1
- Justification:
- whole database is of good quality
- AF for remaining uncertainties:
- 1
- Justification:
- no factor is applied for the uncertainties in genotoxicity, the DNEL is provisional
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.4 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 140 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
No specific metabolism expected, thus oral to dermal extrapolation based on absorption, which is considered 100% for both routes of exposure.
- AF for dose response relationship:
- 1
- Justification:
- Based on derivation of the NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- extrapolation from subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- correction for differences in allometric scaling between rat and human
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA REACH Guidance
- AF for intraspecies differences:
- 5
- Justification:
- ECHA REACH Guidance
- AF for the quality of the whole database:
- 1
- Justification:
- whole database is of good quality
- AF for remaining uncertainties:
- 1
- Justification:
- no factor is applied for the uncertainties in genotoxicity; the DNEL is provisional.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
To protect for corrosion effects to eyes, specific personal protection equipment will be prescribed.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.74 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 87 mg/m³
- Explanation for the modification of the dose descriptor starting point:
No specific metabolism expected, thus oral to inhalation extrapolation based on absorption, which is considered 100% for both routes of exposure.
- AF for dose response relationship:
- 1
- Justification:
- Based on derivation of the NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- extrapolation from subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- no correction for caloric demand for inhalation
- AF for other interspecies differences:
- 2.5
- Justification:
- according to ECHA guidance
- AF for intraspecies differences:
- 10
- Justification:
- standard factor for general population (ECHA)
- AF for the quality of the whole database:
- 1
- Justification:
- whole database is of good quality
- AF for remaining uncertainties:
- 1
- Justification:
- no factor is applied for the uncertainties in genotoxicity; The DNEL is provisional
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No specific metabolism expected, thus oral to dermal extrapolation based on absorption, which is considered 100% for both routes of exposure.
- AF for dose response relationship:
- 1
- Justification:
- Based on derivation of the NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- extrapolation from subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- correction for differences in allometric scaling between rat and human
- AF for other interspecies differences:
- 2.5
- Justification:
- according to ECHA guidance
- AF for intraspecies differences:
- 10
- Justification:
- according to ECHA guidance
- AF for the quality of the whole database:
- 1
- Justification:
- whole database is of good quality
- AF for remaining uncertainties:
- 1
- Justification:
- no factor is applied for the uncertainties in genotoxicity. The DNEL is provisional.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 100 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not relevant
- AF for dose response relationship:
- 1
- Justification:
- Based on derivation of the NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- extrapolation from subchronic to chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- correction for differences in allometric scaling between rat and human
- AF for other interspecies differences:
- 2.5
- Justification:
- according to ECHA guidance
- AF for intraspecies differences:
- 10
- Justification:
- according to ECHA guidance
- AF for the quality of the whole database:
- 1
- Justification:
- whole database is of good quality
- AF for remaining uncertainties:
- 1
- Justification:
- no factor is applied for the uncertainties in genotoxicity. The DNEL is provisional.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - General Population
To protect for corrosion effects to eyes, specific personal protection equipment will be prescribed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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