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EC number: 201-972-0 | CAS number: 90-17-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Principles of method if other than guideline:
- Acute oral toxicity of test chemical in mice.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,2-trichloro-1-phenylethyl acetate
- EC Number:
- 201-972-0
- EC Name:
- 2,2,2-trichloro-1-phenylethyl acetate
- Cas Number:
- 90-17-5
- Molecular formula:
- C10H9Cl3O2
- IUPAC Name:
- 2,2,2-trichloro-1-phenylethyl acetate
- Test material form:
- solid: particulate/powder
- Details on test material:
- Test material identity: 2,2,2-trichloro-1-phenylethyl acetate/ 90-17-5/ 201-972-0
- IUPAC Name: 2,2,2-trichloro-1-phenylethyl acetate
- Common Name: Rosacetone
- InChI: 1S/C10H9Cl3O2/c1-7(14)15-9(10(11,12)13)8-5-3-2-4-6-8/h2-6,9H,1H3
- Smiles: c1([C@@H](OC(C)=O)C(Cl)(Cl)Cl)ccccc1
Details on test material
- Name of test material:Rosacetone
- Molecular formula :C10H9Cl3O2
- Molecular weight :267.538 g/mol
- Substance type:Organic
- Physical state:Solid – Fine white crystalline powder
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4-5 week old
- Fasting period before study: 4 hours
- Housing: The animals were housed individually in cages.
- Diet (e.g. ad libitum): pelleted diet, ad libitum
- Water (e.g. ad libitum): water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: groundnut oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% w/v solution - Doses:
- 2000, 5000 and 10000 mg/kg
- No. of animals per sex per dose:
- Total = 10
2000 mg/kg - one male and one female
5000 mg/kg - three male and three female
10000 mg/kg - one male and one female - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: The animals were observed for signs of toxicity for 7 days. Survivors were weighed before killing for post-mortem examination at the end of the one week observation period.
- Necropsy of survivors performed: yes, all animals dying were autopsied. All survivors were killed and examined post mortem after 7 days. - Statistics:
- The approximate LD50 value is estimated from the results and the test substance is given a toxicity rating according to Hodge and Sterner's classification.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - < 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no further details available
- Mortality:
- At 2000 mg/kg – No mortality was observed.
At 5000 mg/kg – 1 mouse died within 24 hours and 1 mouse died within 96 hours after treatment.
At 10000 mg/kg – Both the mice were died within 48 and 66 hours. - Clinical signs:
- other: At 2000 mg/kg – The male mouse was somnolent, showing signs of stress and exhibiting labored breathing within 18 hours after treatment but recovered within 42 hours. The female mouse appeared unaffected by the treatment. At 5000 mg/kg – The mice were show
- Gross pathology:
- Autopsy of the animals that died revealed gaseous distension and irritation of the stomach and intestines. The mice dying after 48 hours and later had pale soft rose-pink livers, pale spleens and mottled kidneys. Hemorrhaging was also present in the ileum of these mice.
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral toxicity dose LD50 value was considered in between 5000-10000 mg/kg bw, when 10 male and female White mice were treated with test chemical via oral gavage route.
- Executive summary:
The acute oral toxicity of test chemical was tested in 10 male and female White mice at thedose concentration of 2000, 5000 and 10000 mg/kgbw. The given test chemical was dissolved as 20% w/v solutionin groundnut oil and administered via oral gavage route. The animals were observed for signs of toxicity for 7 days. Survivors were weighed before killing for post-mortem examination at the end of the one week observation period. All animals dying were autopsied. All survivors were killed and examined post mortem after 7 days.The approximate LD50 value is estimated from the results and the test substance is given a toxicity rating according to Hodge and Sterner's classification. Mortality was observed as - At 2000 mg/kg – No mortality was observed. At 5000 mg/kg – 1 mouse died within 24 hours and 1 mouse died within 96 hours after treatment. At 10000 mg/kg – Both the mice were died within 48 and 66 hours. Clinical signs were observed such as - At 2000 mg/kg – The male mouse was somnolent, showing signs of stress and exhibiting labored breathing within 18 hours after treatment but recovered within 42 hours. The female mouse appeared unaffected by the treatment. At 5000 mg/kg – The mice were showing signs of stress and exhibiting lacrimation within 30 mins after treatment and within 2 hours somnolence and laboured breathing was also observed. These mice were comatose within 18-42 hours after treatment. The surviving mice continued to show signs of stress throughout the 7 day observation period. At 10000 mg/kg – The mice were showing signs of stress and exhibiting lacrimation within 30 mins after treatment and within 2 hours somnolence and laboured breathing was also observed. These mice were comatose within 18-42 hours after treatment. Surviving animals gained weight during the 7 day observation period and presented a normal appearance at autopsy. Autopsy of the animals that died revealed gaseous distension and irritation of the stomach and intestines. The mice dying after 48 hours and later had pale soft rose-pink livers, pale spleens and mottled kidneys. Hemorrhaging was also present in the ileum of these mice. Therefore, LD50 value was considered in between 5000-10000 mg/kg bw, when 10 male and female White mice were treated with test chemical via oral gavage route.
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