Registration Dossier
Registration Dossier
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EC number: 931-671-6 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No experimental data on toxicokinetics, metabolism and distribution is available for Reaction mass of 2-hexyldecan-1-ol and 2-hexyldodecan-1-ol and 2-octyldecan-1-ol and 2-octyldodecan-1-ol or any other structural analogue of the Guerbet alcohol category. Based on the physical-chemical properties of Guerbet alcohols and the available toxicity data the following assumptions can be made.
The components of Reaction mass of 2-hexyldecan-1-ol and 2-hexyldodecan-1-ol and 2-octyldecan-1-ol and 2-octyldodecan-1-ol have a very low water solubility below 1 mg/l. Therefore the dissolution of the substance is regarded as the rate limiting step for the absorption process from gastrointestinal tract. Amounts of the substance which were absorbed are distributed within the organism by systemic circulation. Due to its lipophilic properties (log Pow > 6) absorbed components of Reaction mass of 2-hexyldecan-1-ol and 2-hexyldodecan-1-ol and 2-octyldecan-1-ol and 2-octyldodecan-1-ol can bind to plasma proteins and a theoretical bioaccumulation in fat tissue cannot totally be excluded, nevertheless the substance is expected to be extensively metabolised.
As first step of the biotransformation of resorbed Reaction mass of 2-hexyldecan-1-ol and 2-hexyldodecan-1-ol and 2-octyldecan-1-ol and 2-octyldodecan-1-ol mainly the oxidation of the alcohols to the corresponding carboxylic acid by phase I enzymes is expected. The carboxylic acids are then expected to be glucoronised by the phase II enzymes UDP-glucuronosyltransferases to the ester glucuronides and excreted. Only minor parts of Reaction mass of 2-hexyldecan-1-ol and 2-hexyldodecan-1-ol and 2-octyldecan-1-ol and 2-octyldodecan-1-ol are expected to be metabolized and excreted as alcohol glucuronides.
This described metabolism is highly efficient and the components of Reaction mass of 2-hexyldecan-1-ol and 2-hexyldodecan-1-ol and 2-octyldecan-1-ol and 2-octyldodecan-1-ol are therefore not expected to have a tissue retention or bioaccumulation potential. This is supported by the available oral subchronic toxicity study of 2-octyldodecan-1-ol which shows no substance-dependent toxic effects at doses of 1 ml/kg bw/d.
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