Registration Dossier
Registration Dossier
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EC number: 207-050-4 | CAS number: 428-59-1
Endpoint summary
Administrative data
Description of key information
In a rat 4-hour acute inhalation study, it was suggested that the test substance was irritating to respiratory tract tissue (mucous membrane) due to nasal discharge observed in all exposure groups.
Key value for chemical safety assessment
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In accordance to REACH Annex XI Section 2; information requirement section 8.1.1 guideline testing for skin or eye irritation is technically not feasible because the test substance is a gas. In a rat 4-hour acute inhalation study, it was suggested that the test substance was irritating to respiratory tract tissue (mucous membrane) due to nasal discharge observed in all exposure groups.
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Data lacking due to waiving arguments, so substance cannot be classified for skin or eye irritation according to the EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. Due to nasal discharge (irritation) in the acute inhalation study, the substance is classified for respiratory irritation Xi;R37 (irritating to respiratory system) according to EU Directive 67/548/EEC and STOT SE 3 according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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