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EC number: 205-492-2 | CAS number: 141-63-9
Data are available for short-term toxicity of the registered substance to fish. A 96 hour LC50 value of >75 ng/L has been determined for effects on mortality of Oncorhynchus mykiss based on mean measured concentrations of the substance in a flow-through test. There are no short-term toxicity data for aquatic invertebrates and algae.
Long-term toxicity data are available for invertebrates, no effects were seen in the long-term study, up to the limit of solubility.
A 21 day EC50 of >47 ng/l and NOEC of ≥47 ng/l have been determined for the effects of the test substance on adult mortality, reproduction and growth of Daphnia magna. The data have been obtained in flow-through tests and are expressed relative to mean measured concentrations of the substance.
These concentrations were measured in test media prepared at a nominal concentration that corresponded with the water solubility of the substance (70 ng/l).
The key result for long-term toxicity in fish is good quality data for the structurally-related substance, decamethyltetrasiloxane (CAS 141-62-8). A 60 day post-hatch NOEC of ≥7.9 µg/l (time weighted mean measured) has been determined for the effects of the structurally-analogous substance, decamethyltetrasiloxane (CAS 141-62-8) on hatching, larval survival, abnormal appearance and behaviour in Oncorhynchus mykiss in the fish early-life stage test (OECD 210).
Short-term aquatic toxicity data for invertebrates is not required because reliable long-term aquatic toxicity data for invertebrates is available.
No data are available with the registered substance on algal inhibition. However, data are available with a structural analogue, decamethyltetrasiloxane (L4, CAS 141-62-8). A 72 hour EC50 value of >2.2 μg/l and NOEC of ≥2.2 μg/l have been determined for the effects of decamethyltetrasiloxane on growth rate of the freshwater algae Pseudokirchneriella subcapitata, based on geometric mean measured concentrations.
Measured long-term sediment toxicity data are available with L5 for three sediment dwelling species; Lumbriculus variegatus, Chironomids riparius and Hyalella azteca:
WoE: 28 day NOEC ≥38 mg/kg dry weight normalised to 5% organic carbon, based on mean measured concentrations, for the effects of L5 on survival and biomass of Lumbriculus variegatus.
WoE: 28 day NOEC ≥27 mg/kg dry weight normalised to 5% organic carbon, based on mean measured concentrations, for the effects of L5 on emergence and combined developmental rate of Chironomus riparius.
WoE: 28 day NOEC ≥59 mg/kg dry weight normalised to 5% organic carbon, based on mean measured concentrations, for the effects of L5 on survival and growth of Hyalella azteca.
There are no reliable data available for toxicity to microorganisms.
A 3 hour EC50 value of >100 mg/l (ASRI) is read-across from the structurally-related substance L4 (CAS 141 -62 -8).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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