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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
RTECS Number: CZ9250000
Author:
Organicke Latky," Marhold, J., Prague
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1052,1986
Reference Type:
review article or handbook
Title:
DPIM: AIE000
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials): Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.:  , 1972, 182.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Standard Draize test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material: 2-aminobenzene-1, 4-disulphonic acid
- Molecular formula: C6H7NO6S2
- Molecular weight: 253.25
- Substance type: Organic

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24 H

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 H
Max. score:
500
Reversibility:
no data
Remarks on result:
other: Mildly irritating

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant)
Remarks:
Migrated information mildly irritating Criteria used for interpretation of results: EU
Conclusions:
2-aminobenzene-1, 4-disulphonic acid is mildly irriatating to rabbit's skin at dose concentration of 500 mg/24H by Standard Draize test.
Executive summary:

2-aminobenzene-1, 4-disulphonic acid is mildly irriatating to rabbit's skin at dose concentration of 500 mg/24H by Standard Draize test and so the substance will qualify for classification in category 2 for skin irritation.