Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes
Author:
Applegate, V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith
Year:
1957
Bibliographic source:
Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC: 157 p.; 1957
Reference Type:
review article or handbook
Title:
Reference Number: 638
Author:
ECOTOX database
Year:
2012
Bibliographic source:
ECOTOX (ECOTOXicology database);Applegate, V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith; Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes; Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC: 157 p.; 1957
Reference Type:
other: QSAR toolbox
Title:
QSAR study for CAS No. : 98-44-2
Author:
QSAR toolbox
Year:
2011
Bibliographic source:
OECD QSAR toolbox version 2.2, 2011; Applegate, V.C., J.H. Howell, A.E.,Jr. Hall, and M.A. Smith; Toxicity of 4,346 Chemicals to Larval Lampreys and Fishes; Spec.Sci.Rep.Fish.No.207, Fish Wildl.Serv., U.S.D.I., Washington, DC;1957

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from QSAR and ECOTOX database.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material: 2-aminobenzene-1, 4-disulphonic acid
- Molecular formula: C6H7NO6S2
- Molecular weight: 253.25
- Substance type: Organic

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
Species Scientific Name: Rainbow Trout
Lifestage: FI
Organism Characteristics: <= 4 in
Species Lifestage: FINGERLING, <= 10 CM

Study design

Test type:
static
Water media type:
freshwater
Total exposure duration:
24 h

Test conditions

Test temperature:
Water Temperature: 55 deg. Fahrenheit
pH:
Water pH: 7.5-8.2
Dissolved oxygen:
Water Dissolved Oxygen: 8.6-13.7 parts per million
Details on test conditions:
ApplicationFrequency: 1 X

Results and discussion

Effect concentrations
Duration:
24 h
Dose descriptor:
NOEC
Effect conc.:
5 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
not specified
Details on results:
No Effect Coded

Applicant's summary and conclusion

Conclusions:
Short term toxicity (24 h) value of 2-aminobenzene-1, 4-disulphonic acid to Oncorhynchus mykiss is NOEC: 5 mg/L (ppm).
Executive summary:

Short term toxicity (24 h) value of 2-aminobenzene-1, 4-disulphonic acid to Oncorhynchus mykiss is NOEC: 5 mg/L (ppm).